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The optimistic scenario assumes: Higher weight-loss efficacy, based on emerging data from trials of AOMs Expanded access to the drug, driving higher uptake assumptions Higher persistency, driven by reduced costs and oral forms of the drug and fewer side effects Lower weight regain after stopping the drug Higher non-weight-loss-related mortality impacts The pessimistic scenario, conversely, considers lower efficacy, lower uptake assumptions, higher and quicker weight regain, and lower non-weight-loss-related mortality impacts